Rapamycin
Rapamycin (Sirolimus) is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
How does it work?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.
Reduces Inflammaging
• Rapamycin lowers chronic low-grade inflammation and may reduce risk of diseases like cancer, Alzheimer’s, cardiovascular disease, and metabolic syndrome.
Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
Benefits
✓ May extend lifespan and delay age-related disease
✓ Supports cellular autophagy and DNA repair
✓ Reduces chronic inflammation (“inflammaging”)
✓ Improves metabolic health and insulin sensitivity
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Frequently Asked Questions
What can I expect with Rapamycin treatment?
Week 2–4: Subtle improvement in recovery, inflammation, skin tone
• Week 6–12: Better metabolic flexibility, energy, and clarity
• 6–12 months: Long-term benefits on insulin sensitivity, lipid markers, and cellular health
• Optimal when combined with Metformin, exercise, time-restricted eating, NAD+ support
• Missed dose? Take on your next scheduled day—do not double dose
What are the possible side effects of Rapamycin?
Common (Usually mild at low/intermittent doses):
• Mouth ulcers or canker sores
• Gastrointestinal discomfort
• Headache or fatigue
• Mild immunosuppression (dose-dependent)
Less Common / Monitor If Present:
• Elevated triglycerides or cholesterol
• Impaired wound healing
• Increased risk of infection at high doses
• Menstrual irregularities
