PT-141
What is PT-141?
PT-141 (Bremelanotide) is a centrally acting melanocortin receptor agonist used to enhance sexual desire and arousal in both men and women. Originally developed to treat sexual dysfunction, it is FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women and is also commonly used off-label in men with low libido or erectile dysfunction—especially when psychological or central causes are suspected. Unlike traditional ED medications, PT-141 works through the brain rather than blood flow.
How does it work?
PT-141 stimulates the brain’s arousal centers through the melanocortin system:
- CNS-Based Arousal Enhancement
• PT-141 activates melanocortin receptors (MC3R and MC4R) in the hypothalamus, increasing sexual desire and drive by acting on the central nervous system. - Independent of Blood Flow
• Unlike PDE5 inhibitors (like sildenafil or tadalafil), PT-141 does not depend on nitric oxide pathways or vascular mechanisms—making it effective for both genders and for arousal-related dysfunction. - Rapid, On-Demand Effect
• Administered via subcutaneous injection 45–60 minutes before sexual activity, PT-141 enhances arousal, responsiveness, and sensitivity for several hours.
Benefits
✓ Increases sexual desire in men and women
✓ Effective for psychological and neurological libido issues
✓ Can help men with ED unresponsive to PDE5 inhibitors
✓ Enhances physical arousal, sensation, and orgasmic response
✓ FDA-approved for HSDD in women
✓ Non-hormonal and well tolerated
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Frequently Asked Questions
What can I expect with PT-141 treatment?
• Inject 1 hour before sexual activity (typically 1.75mg dose)
• Onset: 45–60 minutes, duration: 6–12 hours
• Do not exceed 1 dose in 24 hours or 8 doses per month (per FDA guidelines for women)
• Results improve with repeated, consistent use over time
• Safe to combine with TRT, HRT, or PDE5s (under supervision)
• Missed dose? PT-141 is on-demand—only use when needed
What are the possible side effects of PT-141?
Common Side Effects:
• Nausea (transient)
• Flushing or warmth
• Headache
• Injection site reactions
Less Common / Monitor If Present:
• Elevated blood pressure (temporary)
• Fatigue or yawning
• Dizziness
• Darkening of gums or skin (rare with prolonged use)
